Open and endoscopic carpal-tunnel releases are commonly used as the definitive treatment for carpal tunnel syndrome. This ...

Read before the Boston Society for Medical Improvement, November 24, 1890.

For over 200 years, the New England Journal of Medicine (NEJM) has brought important medical news to the world’s most influential physicians. The global medical community, physicians, and ...

Amid growing interest in unionization and recent strike activity among physicians, policies could be updated to better reflect the realities of modern health care and incorporate lessons from ...

Currently approved triglyceride-lowering medications provide minimal benefit for patients with persistent chylomicronemia. New research findings on plozasiran, a small interfering RNA, are ...

New catheter materials for peripherally inserted central catheters (PICCs) may reduce the risk of device failure due to infectious, thrombotic, and catheter occlusion events. However, data from ...

Allogeneic hematopoietic stem-cell transplantation is the only curative treatment for myelofibrosis. Driver mutations are the pathophysiological hallmark of the disease, but the role of mutation ...

Talquetamab is a T-cell–redirecting bispecific antibody targeting G protein–coupled receptor class C group 5 member D (GPRC5D). 13-15 In the MonumenTAL-1 study, more than 71% of the patients ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...